Evaluation of the Anti-ulcer and to Buettneri in Laboratory Animals

The anti-ulcerogenic potential of the leaf metha Berger was investigated using three methods of gastric Wistar rats (150-200 g) and mice (20-25 g): 1. HCl/e Indomethacin-HCl/ethanol-induced gastric lesions, a gastric lesions. Mice were used in acute and sub acute t of the extract of Aloe buettneri to the rats and mice (50 prevented the formation of acute gastric lesions induc techniques. The dose-dependent reduction of lesion fo significant increase in gastric mucus production in mic was 22 and 54 % in mice, 25 and 77% in rats for the do the HCl/ethanol mixture was given. Pre-treatment, by significantly reduced the ability of the extract to inhib induced lesions, inhibition dropping to 11% for the dos were subjected to pylorus ligation, the level of lesion in two doses of extract. Gastric acid secretion reduced to 88 mEq/l for the controls. Acute toxicity studies did not rev 10 g/kg. However, sub acute studies revealed toxicity e (diffuse alveolar disease) and liver (chronic active hepat the ethnomedical use of Aloe buettneri in the mana disease and suggest that toxic effects may result from p the extract.